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. 2010 Nov-Dec;16(6):651-74.
doi: 10.1093/humupd/dmq009. Epub 2010 May 12.

Peripheral biomarkers of endometriosis: a systematic review

K E May  1 , S A Conduit-Hulbert, J Villar, S Kirtley, S H Kennedy, C M Becker
Affiliations

Peripheral biomarkers of endometriosis: a systematic review

K E May et al. Hum Reprod Update. 2010 Nov-Dec.

Abstract

Background: Endometriosis is estimated to affect 1 in 10 women during the reproductive years. There is often delay in making the diagnosis, mainly due to the non-specific nature of the associated symptoms and the need to verify the disease surgically. A biomarker that is simple to measure could help clinicians to diagnose (or at least exclude) endometriosis; it might also allow the effects of treatment to be monitored. If effective, such a marker or panel of markers could prevent unnecessary diagnostic procedures and/or recognize treatment failure at an early stage.

Methods: We used QUADAS (Quality Assessment of Diagnostic Accuracy Studies) criteria to perform a systematic review of the literature over the last 25 years to assess critically the clinical value of all proposed biomarkers for endometriosis in serum, plasma and urine.

Results: We identified over 100 putative biomarkers in publications that met the selection criteria. We were unable to identify a single biomarker or panel of biomarkers that have unequivocally been shown to be clinically useful.

Conclusions: Peripheral biomarkers show promise as diagnostic aids, but further research is necessary before they can be recommended in routine clinical care. Panels of markers may allow increased sensitivity and specificity of any diagnostic test.

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Figures

Figure 1
Figure 1
Flow diagram depicting selection of articles for review.
Figure 2
Figure 2
Spider diagram depicting putative biomarkers.
See this image and copyright information in PMC

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