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. 2010 Jul;84(14):7412-5.
doi: 10.1128/JVI.02548-09. Epub 2010 May 12.

HIV-2 genetic evolution in patients with advanced disease is faster than that in matched HIV-1 patients

Helena Skar  1 , Pedro Borrego, Timothy C Wallstrom, Mattias Mild, José Maria Marcelino, Helena Barroso, Nuno Taveira, Thomas Leitner, Jan Albert
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HIV-2 genetic evolution in patients with advanced disease is faster than that in matched HIV-1 patients

Helena Skar et al. J Virol. 2010 Jul.

Abstract

The objective of this study was to estimate and compare the evolutionary rates of HIV-2 and HIV-1. Two HIV-2 data sets from patients with advanced disease were compared to matched HIV-1 data sets. The estimated mean evolutionary rate of HIV-2 was significantly higher than the estimated rate of HIV-1, both in the gp125 and in the V3 region of the env gene. In addition, the rate of synonymous substitutions in gp125 was significantly higher for HIV-2 than for HIV-1, possibly indicating a shorter generation time or higher mutation rate of HIV-2. Thus, the lower virulence of HIV-2 does not appear to translate into a lower rate of evolution.

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