Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2010 Spring;22(2):188-95.
doi: 10.1176/jnp.2010.22.2.188.

The impact of antidepressant treatment on cognitive functioning in depressed patients with Parkinson's disease

Roseanne DeFronzo Dobkin  1 , Matthew Menza, Karina L Bienfait, Michael Gara, Humberto Marin, Margery H Mark, Allison Dicke, Alexander Tröster
Affiliations
Randomized Controlled Trial

The impact of antidepressant treatment on cognitive functioning in depressed patients with Parkinson's disease

Roseanne DeFronzo Dobkin et al. J Neuropsychiatry Clin Neurosci. 2010 Spring.

Abstract

Depression is associated with more rapid cognitive decline in Parkinson's disease. The goal of this study was to examine the impact of the acute (8-week) and longer-term (24-week) antidepressant treatment on cognition in Parkinson's disease and to detail cognitive predictors of treatment response. Fifty-two depressed Parkinson's disease patients were enrolled in an NIH-funded randomized, controlled trial of nortriptyline, paroxetine, and placebo. Neuropsychological testing was performed at baseline and weeks 8 and 24. Higher baseline scores on measures of executive functioning, speed of processing, and verbal memory were associated with antidepressant response. Treatment responders did not exhibit larger gains in cognition than nonresponders. Findings warrant replication.

Trial registration: ClinicalTrials.gov NCT00062738.

PubMed Disclaimer

References

    1. Cummings JL. Depression and Parkinson’s disease. Am J Psychiatry. 1992;149:443–454. - PubMed
    1. Tandberg E, Larsen JP, Aarsland D, et al. The occurrence of depression in Parkinson’s disease. A community-based study. Arch Neurol. 1996;53:175–179. - PubMed
    1. Dooneief G, Mirabello E, Bell K, et al. An estimate of the incidence of depression in idiopathic Parkinson’s disease. Arch Neurol. 1992;49:305–307. - PubMed
    1. Ravina B, Camicioli R, Como PG, et al. The impact of depressive symptoms in early Parkinson disease. Neurology. 2007;69(4):342–347. - PMC - PubMed
    1. Whetten-Goldstein K, Sloan F, Kulas E, et al. The burden of Parkinson’s disease on society, family, and the individual. J Am Geriatr Soc. 1997;45(7):844–849. - PubMed

Publication types

MeSH terms

Associated data