Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Apr 26:4:321-6.
doi: 10.2147/opth.s9546.

Intracameral vancomycin following cataract surgery: An eleven-year study

Deepa R Anijeet  1 , Prasad Palimar, Clive O Peckar
Affiliations

Intracameral vancomycin following cataract surgery: An eleven-year study

Deepa R Anijeet et al. Clin Ophthalmol. .

Abstract

Aim: To compare the incidences of endophthalmitis after cataract operations before and after introduction of intracameral vancomycin at the end of surgery.

Methods: A retrospective analysis was performed of presumed infectious endophthalmitis after cataract surgery from January 1, 1998 to December 31, 2008. From January 2001, the practice of using intracameral vancomycin at the end of cataract surgery was introduced. The period before introduction of intracameral vancomycin is considered as period A and that after as period B. The incidences of presumed or culture-proven endophthalmitis during periods A and B were compared.

Results: A total of 16,606 cataract surgeries were performed during the study period. The incidence of endophthalmitis per 1000 cataract surgeries was 3.0 during period A and 0.08 during period B. This reduction was statistically significantly (Chi-squared test 36.6, P value < 0.0001). The relative risk of developing endophthalmitis without intracameral vancomycin prophylaxis was 38. The absolute risk reduction was 292 cases of endophthalmitis per 100,000 cataract surgeries.

Conclusions: Intracameral vancomycin significantly reduced the incidence of postoperative endophthalmitis after cataract surgery. There is a universal need to adopt this mode of microbial prophylaxis to reduce the burden of endophthalmitis after cataract surgery.

Keywords: cataract surgery; endophthalmitis; intracameral vancomycin.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Distribution of number cataract surgeries performed over the study period.
Figure 2
Figure 2
Distribution of cases of endophthalmitis over the study period showing cumulative incidence.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Endophthalmitis Vitrectomy Study Group. Results of the Endopthalmitis Vitrectomy Study: A randomized trial of immediate vitrectomy and of intravenous antibiotics for the treatment of postoperative bacterial endophthalmitis. Arch Ophthalmology. 1995;113:1479–1496. - PubMed
    1. Taban M, Beherens A, Newcomb RL, et al. Acute endophthalmitis following cataract surgery: A systematic review of the literature. Arch Ophthalmol. 2005;123:613–620. - PubMed
    1. Hatch WV, Cernat G, Wong D, Devenyi R, Bell CM. Risk factors for acute endophthalmitis after cataract surgery: A population-based study. Ophthalmology. 2009;116:425–430. - PubMed
    1. Miller JJ, Scott IU, Flynn HW, Jr, Smiddy WE, Newton J, Miller D. Acute onset endophthalmitis after cataract surgery (2000–2004): Incidence, clinical settings, and visual acuity outcomes after treatment. Am J Ophthalmol. 2005;139:983–987. - PubMed
    1. Barry P, Seal DV, Gettinby G, Lees F, Peterson M, Revie CW. ESCRS study of prophylaxis of postoperative endophthalmitis after cataract surgery: Preliminary report of principal results from a European multicenter study; the ESCRS Endophthalmitis Study Group. J Cataract Refract Surg. 2006;32:407–410. - PubMed

LinkOut - more resources