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. 2010 Apr 7:5:213-20.
doi: 10.2147/ijn.s8611.

A preliminary study of the use of bioimpedance in the screening of squamous tongue cancer

Congo Tak-Shing Ching  1 , Tai-Ping Sun, Su-Hua Huang, Chin-Sung Hsiao, Ching-Haur Chang, Shiow-Yuan Huang, Yi-Juai Chen, Chi-Sheng Cheng, Hsiu-Li Shieh, Chung-Yuan Chen
Affiliations

A preliminary study of the use of bioimpedance in the screening of squamous tongue cancer

Congo Tak-Shing Ching et al. Int J Nanomedicine. .

Abstract

Oral cancers are the 11th most common malignancy reported worldwide, accounting for 3% of all newly diagnosed cancer cases, and one with high mortality ratios among all malignancies. The objective of this study was to study the electrical properties of cancerous tongue tissue (CTT) and normal tongue tissue (NTT). Five tongue cancer patients participated in this study. A disposable probe incorporating four silver electrodes was used to measure the electrical properties of CTT and the surrounding NTT of patients. Measurements were performed at six frequencies: 20 Hz; 50 kHz; 1.3 MHz; 2.5 MHz; 3.7 MHz; and 5 MHz, with the amplitude of the applied voltage limited to 200mV. Four measurement parameters of impedance (Z), phase angle (theta), real part of impedance (R), and imaginary part of impedance (X) of tongue tissue were assessed to see if there was any significant difference in the values obtained in CTT and surrounding NTT. The intraclass correlation coefficient showed that all measurements were reliable. A significant difference (P < 0.05 for the four measurement parameters) was found at 50kHz between CTT and surrounding NTT. It was also found that Z and R of CTT were generally smaller than that of surrounding NTT. In conclusion, bioimpedance at a particular frequency is a potentially promising technique for tongue cancer screening.

Keywords: bioimpedance; cancer; detection; noninvasive; screening; tongue.

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Figures

Figure 1
Figure 1
The four-electrode disposable probe.
Figure 2
Figure 2
Impedance and phase angle of cancerous and surrounding normal tongue tissues measured at different frequencies. Results were expressed as means and standard deviations. Statistically significant differences between cancerous and surrounding normal tongue tissues were shown, with P < 0.05 represented by* and P < 0.001 represented by**.
Figure 3
Figure 3
Real and imaginary part of impedance of cancerous and surrounding normal tongue tissues measured at different frequencies. Results were expressed as means and standard deviations. Statistically significant differences between cancerous and surrounding normal tongue tissues were shown, with p < 0.05 represented by* and p < 0.001 represented by**.
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References

    1. Lumerman H, Freedman P, Kerpel S. Oral epithelial dysplasia and the development of invasive squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontics. 1995;79:321–329. - PubMed
    1. Parkin DM, Bray F, et al. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74–108. - PubMed
    1. Badizadegan K, Backman V, et al. Spectroscopic diagnosis and imaging of visible precancers. Faraday Discuss. 2004;126:265–279. - PubMed
    1. Staveren HJ van, Veen RLP van, et al. Classification of clinical autoflourescence spectra of oral leucoplakia using an artificial neural network: a pilot study. Oral Oncol. 2000;36:286–293. - PubMed
    1. Lau DP, Huang Z, et al. Raman spectroscopy for optical diagnosis in normal and cancerous tissue of the nasopharynx-preliminary findings. Lasers Surg Med. 2003;32:210–214. - PubMed

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