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. 2010 Mar-Apr;52(2):89-93.
doi: 10.1590/s0036-46652010000200005.

Leishmanicidal activity of Echinaster (Othilia) echinophorus crude extract

Marley García Parra  1 , Lianet Monzote Fidalgo, Judith Mendiola Martinez, Ana Margarita Montalvo Alvarez, Olga Valdés Iglesias
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Free article

Leishmanicidal activity of Echinaster (Othilia) echinophorus crude extract

Marley García Parra et al. Rev Inst Med Trop Sao Paulo. 2010 Mar-Apr.
Free article

Abstract

In this study, a methanolic extract from Echinaster (Othilia) echinophorus was evaluated for activity against Leishmania amazonensis. The extract showed activity against the promastigote and amastigote forms with IC50 values of 62.9 and 37.5 microg.mL-1 respectively. This extract showed a moderate toxicity on macrophages from BALB/c mice. A dose of 100 mg/kg/day was effective when administered during 15 days by intraperitoneal route to BALB/c mice infected experimentally.

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