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. 2010 Mar-Apr;43(2):121-4.
doi: 10.1590/s0037-86822010000200003.

Extended-spectrum beta-lactamase-producing Salmonella enterica serovar Oranienburg (CTX-M-2 group) in a pediatric hospital in Tucumán, Argentina

María Angela Jure  1 , Olga Aulet, Ana Trejo, Marta Castillo
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Free article

Extended-spectrum beta-lactamase-producing Salmonella enterica serovar Oranienburg (CTX-M-2 group) in a pediatric hospital in Tucumán, Argentina

María Angela Jure et al. Rev Soc Bras Med Trop. 2010 Mar-Apr.
Free article

Abstract

Introduction: Salmonella sp infections have been reported over recent years in hospitals in Argentina and other countries due to multiresistant strains. The aim of this study was to characterize the extended-spectrum beta-lactamases in third-generation cephalosporin-resistant strains of Salmonella enterica serovar Oranienburg.

Methods: We studied 60 strains isolated from children with gastroenteritis and/or extraintestinal complications. The antibiotic susceptibility patterns of the isolates were analyzed and the beta-lactamases were characterized using phenotyping and genotyping methods.

Results: All the strains were resistant to ampicillin, cefotaxime, cefepime and aztreonam and partially susceptible to ceftazidime, thus corresponding well with the resistance phenotype conferred by CTX-M-type beta-lactamases. An isoelectric point enzyme (pI = 7.9) was detected in all of the strains, and this was confirmed by PCR as a member of the CTX-M-2 group.

Conclusions: This is the first report of Salmonella enterica serovar Oranienburg producing beta-lactamases of the CTX-M-2 group in a pediatric hospital in Tucumán, Argentina.

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