Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Jul;12(4):267-72.
doi: 10.1007/s11883-010-0112-9.

Metabolomics and atherosclerosis

Sascha N Goonewardena  1 , Lisa E Prevette, Ankit A Desai
Affiliations
Review

Metabolomics and atherosclerosis

Sascha N Goonewardena et al. Curr Atheroscler Rep. 2010 Jul.

Abstract

Metabolites reflect the dynamic processes underlying cellular homeostasis. Recent advances in analytical chemistry and molecular biology have set the stage for metabolite profiling to help us understand complex molecular processes and physiology. Metabolomics is the comparative analysis of metabolite flux and how it relates to biological phenotypes. As an intermediate phenotype, metabolite signatures capture a unique aspect of cellular dynamics that is not typically interrogated, providing a distinct perspective on cellular homeostasis. To date, there have been only a few metabolomics studies investigating cardiovascular diseases. In this review, we explore the principles of metabolomics and how it can provide further insight into the mechanisms of cardiovascular physiology and ultimately lead to improved diagnostic and therapeutic options for patients with cardiovascular disease.

PubMed Disclaimer

Conflict of interest statement

Disclosure No potential conflicts of interest relevant to this article were reported.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Schadt EE. Molecular networks as sensors and drivers of common human diseases. Nature. 2009;461:218–223. This review highlights the need to integrate data sets and variables to further our understanding of complex diseases using a systems biology approach. - PubMed
    1. Muoio DM, Newgard CB. Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol. 2008;9:193–205. - PubMed
    1. Bain JR, Stevens RD, Wenner BR, et al. Metabolomics applied to diabetes research: moving from information to knowledge. Diabetes. 2009;58:2429–2443. - PMC - PubMed
    1. Aranibar N, Ott KH, Roongta V, Mueller L. Metabolomic analysis using optimized NMR and statistical methods. Anal Biochem. 2006;355:62–70. - PubMed
    1. Nicholson JK, Lindon JC. Systems biology: metabonomics. Nature. 2008;455:1054–1056. - PubMed