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Review
. 2010 Aug;10(4):276-82.
doi: 10.1007/s11892-010-0120-8.

DCCT and EDIC studies in type 1 diabetes: lessons for diabetic neuropathy regarding metabolic memory and natural history

Rodica Pop-Busui  1 , William H Herman, Eva L Feldman, Phillip A Low, Catherine L Martin, Patricia A Cleary, Barbara H Waberski, John M Lachin, James W Albers; DCCT/EDIC Research Group
Affiliations
Review

DCCT and EDIC studies in type 1 diabetes: lessons for diabetic neuropathy regarding metabolic memory and natural history

Rodica Pop-Busui et al. Curr Diab Rep. 2010 Aug.

Abstract

The DCCT/EDIC (Diabetes Control and Complications Trial/ Epidemiology of Diabetes Interventions and Complications) provides a comprehensive characterization of the natural history of diabetic neuropathy in patients with type 1 diabetes and provides insight into the impact of intensive insulin therapy in disease progression. The lessons learned about the natural history of distal symmetrical polyneuropathy and cardiovascular autonomic neuropathy and the impact of glycemic control on neuropathy are discussed in this review.

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Conflict of interest statement

No other potential conflicts of interest relevant to this article were reported.

Figures

Fig. 1
Fig. 1
Flow diagram of NeuroEDIC (neuropathy assessments during EDIC) participation. The four gold-colored boxes illustrate the subjects who had evaluations in EDIC year 13/14. CAN—cardiovascular autonomic neuropathy; DCCT—Diabetes Control and Complications Trial; DSPN—distal symmetrical polyneuropathy; EDIC—Epidemiology of Diabetes Interventions and Complications
See this image and copyright information in PMC

References

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