miRNAs as molecular biomarkers of cancer

Abstract

miRNAs are noncoding RNAs that regulate gene expression. The advent of high-throughput techniques has revealed that miRNA expression is deregulated in almost all human tumors (both solid and hematologic) with respect to the normal tissue counterpart. These differences frequently recur in tumor-specific miRNA signatures, which are very helpful to diagnose the tissue of origin of the neoplasia, and sometimes also specific tumor subtypes. Increasing evidence also supports a role for miRNAs as prognostic biomarkers of human cancers. Finally, miRNAs are differentially expressed in the blood of cancer patients versus healthy donors, providing a rationale for the detection of miRNAs and diagnostic and prognostic circulating biomarkers.