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. 2010 May 13:5:17.
doi: 10.1186/1749-8546-5-17.

Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian)

Wen-Wan Chao  1 , Bi-Fong Lin
Affiliations

Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian)

Wen-Wan Chao et al. Chin Med. .

Abstract

Andrographis paniculata (Burm. f.) Nees (Acanthaceae) is a medicinal plant used in many countries. Its major constituents are diterpenoids, flavonoids and polyphenols. Among the single compounds extracted from A. paniculata, andrographolide is the major one in terms of bioactive properties and abundance. Among the andrographolide analogues, 14-deoxy-11,12-didehydroandrographolide is immunostimulatory, anti-infective and anti-atherosclerotic; neoandrographolide is anti-inflammatory, anti-infective and anti-hepatotoxic; 14-deoxyandrographolide is immunomodulatory and anti-atherosclerotic. Among the less abundant compounds from A. paniculata, andrograpanin is both anti-inflammatory and anti-infective; 14-deoxy-14,15-dehydroandrographolide is anti-inflammatory; isoandrographolide, 3,19-isopropylideneandrographolide and 14-acetylandrographolide are tumor suppressive; arabinogalactan proteins are anti-hepatotoxic. The four flavonoids from A. paniculata, namely 7-O-methylwogonin, apigenin, onysilin and 3,4-dicaffeoylquinic acid are anti-atherosclerotic.

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Figures

Figure 1
Figure 1
Structures and bioactivities of compounds isolated from A. paniculata.
Figure 2
Figure 2
Structures and bioactivities of flavonoids isolated from A. paniculata.
Figure 3
Figure 3
Extraction procedure for the isolation and identification A. paniculata pure compounds from EtOAc extract. Dried whole plant of A. paniculata is pre-extracted with 95% ethanol and then partitioned in EtOAc/H2O for further fractionation.
Figure 4
Figure 4
Structures and bioactivities of synthesized analogues.
See this image and copyright information in PMC

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