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Review
. 2010 Nov;22(11):1615-25.
doi: 10.1016/j.cellsig.2010.05.002. Epub 2010 May 11.

Endothelin--biology and disease

Al-Karim Khimji  1 , Don C Rockey
Affiliations
Review

Endothelin--biology and disease

Al-Karim Khimji et al. Cell Signal. 2010 Nov.

Abstract

Endothelins are important mediators of physiological and pathophysiologic processes including cardiovascular disorders, pulmonary disease, renal diseases and many others. Additionally, endothelins are involved in many other important processes such as development, cancer biology, wound healing, and even neurotransmission. Here, we review the cell and molecular biology as well as the prominent pathophysiological aspects of the endothelin system.

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