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Case Reports
. 2010 Jul;25(7):2376-8.
doi: 10.1093/ndt/gfq224. Epub 2010 Apr 20.

Acute renal failure and Fanconi syndrome due to deferasirox

Steven Grangé  1 , Dominique M Bertrand, Dominique Guerrot, Florence Eas, Michel Godin
Affiliations
Case Reports

Acute renal failure and Fanconi syndrome due to deferasirox

Steven Grangé et al. Nephrol Dial Transplant. 2010 Jul.

Abstract

Deferasirox is the first oral iron chelator and, as such, is widely used for the treatment of chronic iron overload. However, recent data from large studies confirmed the renal toxicity of deferasirox. We report a case of Fanconi syndrome associated with acute renal failure in a patient receiving deferasirox. In particular, new insights regarding the pathophysiology of the renal disease due to this treatment are discussed. This case highlights the importance of a careful monitoring of kidney function, markers of proximal tubulopathy and ferritinaemia in patients receiving deferasirox.

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