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Comment
. 2010 Jun;11(6):411-2.
doi: 10.1038/embor.2010.76. Epub 2010 May 14.

Checkpoint recovery after DNA damage: a rolling stop for CDKs

Anja M Duursma  1 , Karlene A Cimprich
Affiliations
Comment

Checkpoint recovery after DNA damage: a rolling stop for CDKs

Anja M Duursma et al. EMBO Rep. 2010 Jun.

Abstract

The cell cycle machinery has to be arrested for efficient repair of DNA damage. A paper in this issue of EMBO reports demonstrates that residual CDK activity is nevertheless required during arrest for activation of FoxM1, which is essential for cell-cycle progression after the damage has been repaired.

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Figures

Figure 1
Figure 1
Model for regulation of cyclin-dependent kinase and FoxM1. Feedback cycles after (A) DNA damage, (B) checkpoint recovery and (C) recovery with reduced levels of CDK or FoxM1. See text for details. Arrow size represents strength of the signal. CDK, cyclin-dependent kinase; P, phosphate group.
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Comment on

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