Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Jun;8(6):393-9.
doi: 10.1038/nrmicro2366.

Molecular mechanisms of complement evasion: learning from staphylococci and meningococci

Davide Serruto  1 , Rino Rappuoli, Maria Scarselli, Piet Gros, Jos A G van Strijp
Affiliations

Molecular mechanisms of complement evasion: learning from staphylococci and meningococci

Davide Serruto et al. Nat Rev Microbiol. 2010 Jun.

Abstract

The complement system is a crucial component of the innate immune response in humans. Recent studies in Staphylococcus aureus and Neisseria meningitidis have revealed how these bacteria escape complement-mediated killing. In addition, new structural data have provided detailed insights into the molecular mechanisms of host defence mediated by the complement system and how bacterial proteins interfere with this process. This information is fundamental to our understanding of bacterial pathogenesis and may facilitate the design of better vaccines.

PubMed Disclaimer

References

    1. Nature. 2006 Nov 9;444(7116):213-6 - PubMed
    1. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6194-9 - PubMed
    1. J Immunol. 2008 Aug 15;181(4):2610-9 - PubMed
    1. Nature. 2005 Sep 22;437(7058):505-11 - PubMed
    1. Nat Immunol. 2009 Jul;10(7):728-33 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources