[Interaction of viruses and Toll-like receptors]

Abstract

Despite the numerous ways the host defended viral infections, which mediated through reactions of innate and adaptive immunity, viruses escape from immune surveillance by interacting with receptor molecules of immune system for penetration into a cell and activation of synthetic processes in it for realization of early stages of viral replication. Recently, data about signaling receptors of innate immunity--Toll-like receptors (TLRs), which participate in recognition of conservative molecules of pathogenic microorganisms including viruses, were published. In this review several variants of effects of viruses (paramyxovirus, cytomegalovirus, smallpox virus, measles virus, and others) on TLR-mediated mechanisms of innate immunity are presented. Obtained data can be used for development of new antiviral drugs as well as vaccines.