A clinical profile of fibrocalculous pancreatic diabetes patients from eastern India with special reference to body fat percentage and insulin resistance

Abstract

Fibrocalculous pancreatic diabetes though less commonly seen but is a unique form of diabetes seen mostly in the tropics. Thirty-one (19 males, 12 females) consecutive patients attending the OPD were evaluated for clinical and biochemical profile with special reference to quantifying insulin resistance (by HOMA-IR) and body fat percentage (by bioimpedence). Insulin requirement was found to be 1.15 +/- .33 units/kg. HOMA-IR was abnormal (>2) in 24 (77.42%). Increased body fat percentage (defined as >20% in males and >30% in females) was found in 17 males (89.5%) out of 19 and in 4 females (33.3%) out of 12. There was significant positive correlation between HOMA-IR and body fat (by between feet method p < 0.001) and by between hands method (p = 0.01).