Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Sep;157(3):499-501, 501.e1.
doi: 10.1016/j.jpeds.2010.04.011. Epub 2010 May 15.

Therapeutic hypothermia for neonatal encephalopathy and extracorporeal membrane oxygenation

An Massaro  1 , Khodayar Rais-Bahrami, Taeun Chang, Penny Glass, Billie Lou Short, Stephen Baumgart
Affiliations

Therapeutic hypothermia for neonatal encephalopathy and extracorporeal membrane oxygenation

An Massaro et al. J Pediatr. 2010 Sep.

Abstract

This case series describes the clinical management of 5 infants who underwent whole-body cooling during extracorporeal membrane oxygenation (ECMO). In all 5 infants, systemic hypothermia was maintained during ECMO with acceptable clinical outcomes.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Temperature using ECMO Circuit Combined with Cooling Blanket to maintain hypothermia on ECMO. Note variation in axillary temperature while continuous esophageal monitored temperature is tightly controlled and approximates blood temperature. **** Initial 4 hours of cooling are presented in larger scale to demonstrate initial overshoot to 32°C with induction of hypothermia. This is typically observed prior to equilibration [2] and captured when temperature is recorded every 15 minutes in the first 4 hours of hypothermia.
See this image and copyright information in PMC

Comment in

  • Hypothermic neural rescue: work continues.
    Edwards AD, Azzopardi DV. Edwards AD, et al. J Pediatr. 2010 Sep;157(3):351-2. doi: 10.1016/j.jpeds.2010.06.029. Epub 2010 Jul 24. J Pediatr. 2010. PMID: 20659738 No abstract available.

References

    1. Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF, et al. Whole body hypothermia for neonates with hypoxic ischemic encephalopathy. N Engl J Med. 2005;353:1574–84. - PubMed
    1. Shankaran S, Pappas A, Laptook AR, McDonald SA, Ehrenkranz RA, Tyson JE, et al. Outcomes of safety and effectiveness in a multicenter, randomized controlled trial of whole-body hypothermia for neonatal hypoxic-ischemic encephalopathy. Pediatrics. 2008;122:e791–8. - PMC - PubMed
    1. Jacobs S, Hunt R, Tarnow-Mordi W, Inder T, Davis P. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev. 2007:CD003311. - PubMed
    1. Wiswell TE, Bent RC. Meconium staining and meconium aspiration syndrome. Ped Clin North Am. 1993;40:955–981. - PubMed
    1. McNally H, Bennett CC, Elbourne D, Field DJ. United Kingdom collaborative randomized trial of neonatal extracorporeal membrane oxygenation: follow-up to age 7 years. Pediatrics. 2006;117:e845–854. - PubMed