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Clinical Trial
. 2010 Jul;120(1-3):210-6.
doi: 10.1016/j.schres.2010.03.042. Epub 2010 May 15.

One-year durability of the effects of cognitive enhancement therapy on functional outcome in early schizophrenia

Shaun M Eack  1 , Deborah P Greenwald, Susan S Hogarty, Matcheri S Keshavan
Affiliations
Clinical Trial

One-year durability of the effects of cognitive enhancement therapy on functional outcome in early schizophrenia

Shaun M Eack et al. Schizophr Res. 2010 Jul.

Abstract

Cognitive rehabilitation is an effective intervention for addressing cognitive impairments in patients with schizophrenia. Previous research has shown that the early application of Cognitive Enhancement Therapy (CET) can improve neurocognitive and social-cognitive deficits in the early course of the disorder, and ultimately reduce the substantial functional disability that these patients experience. However, the lasting effects of CET on functional outcome in early course schizophrenia patients remain unknown. In this study, 58 patients in the early course of schizophrenia or schizoaffective disorder treated with 2 years of either CET or an Enriched Supportive Therapy (EST) control were followed-up 1 year after the completion of treatment to examine the durability of CET effects on functional outcome. At one-year post-treatment, a high (72%) retention rate was observed in both treatments. Results from intent-to-treat analyses employing linear mixed-effects models indicated that CET effects on functional outcome were broadly maintained one-year post-treatment, and that patients receiving CET continued to demonstrate highly significant differential functional benefits compared to patients treated with EST. These findings support the durability of CET effects on functional outcome in the early course of schizophrenia, and point to the potential of cognitive rehabilitation to have a lasting impact on the early trajectory of the disorder.

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Conflict of interest statement

Conflict of Interest

The authors report no conflicts of interest.

Figures

Figure 1
Figure 1
One-Year Durability of the Effects of Cognitive Enhancement Therapy or Enriched Supportive Therapy on Social Adjustment
See this image and copyright information in PMC

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