Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2010 Jul;299(1):H10-2.
doi: 10.1152/ajpheart.00436.2010. Epub 2010 May 14.

Endothelial Nrf2 activation: a new target for resveratrol?

György Haskó, Pál Pacher
Editorial

Endothelial Nrf2 activation: a new target for resveratrol?

György Haskó et al. Am J Physiol Heart Circ Physiol. 2010 Jul.
No abstract available

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Potential targets of beneficial effects of resveratrol in cardiovascular disease. SIRT1, silent information regulator 2/sirtuin 1; eNOS, endothelial nitric oxide (NO) synthase; Nrf2, NF-E2-related factor-2; ARE, antioxidant response element; ROS, reactive oxygen species; NQO1, NAD(P)H:quinone-oxidoreductase 1.
See this image and copyright information in PMC

Comment on

References

    1. Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell 120: 483–495, 2005 - PubMed
    1. Barger JL, Kayo T, Vann JM, Arias EB, Wang J, Hacker TA, Wang Y, Raederstorff D, Morrow JD, Leeuwenburgh C, Allison DB, Saupe KW, Cartee GD, Weindruch R, Prolla TA. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS One 3: e2264, 2008 - PMC - PubMed
    1. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444: 337–342, 2006 - PMC - PubMed
    1. Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 5: 493–506, 2006 - PubMed
    1. Bradamante S, Barenghi L, Piccinini F, Bertelli AA, De Jonge R, Beemster P, De Jong JW. Resveratrol provides late-phase cardioprotection by means of a nitric oxide- and adenosine-mediated mechanism. Eur J Pharmacol 465: 115–123, 2003 - PubMed

MeSH terms