Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Jul;192(14):3822-3.
doi: 10.1128/JB.00280-10. Epub 2010 May 14.

Frequency and rate of pilin antigenic variation of Neisseria meningitidis

R Allen Helm  1 , H Steven Seifert
Affiliations

Frequency and rate of pilin antigenic variation of Neisseria meningitidis

R Allen Helm et al. J Bacteriol. 2010 Jul.

Abstract

The rates of pilin antigenic variation (Av) of two strains of Neisseria meningitidis were determined using an unbiased DNA sequencing assay. Strain MC58 underwent pilin Av at a rate similar to that of N. gonorrhoeae strain MS11 but lower than that of N. gonorrhoeae strain FA1090. Pilin Av was undetectable in strain FAM18.

PubMed Disclaimer

References

    1. Aho, E. L., and J. G. Cannon. 1988. Characterization of a silent pilin gene locus from Neisseria meningitidis strain FAM18. Microb. Pathog. 5:391-398. - PubMed
    1. Anonymous. 1998. Control of epidemic meningococcal disease. WHO practical guidelines, 2nd ed. World Health Organization, Geneva, Switzerland.
    1. Cahoon, L. A., and H. S. Seifert. 2009. An alternative DNA structure is necessary for pilin antigenic variation in Neisseria gonorrhoeae. Science 325:764-767. - PMC - PubMed
    1. Cehovin, A., M. Winterbotham, J. Lucidarme, R. Borrow, C. M. Tang, R. M. Exley, and V. Pelicic. Sequence conservation of pilus subunits in Neisseria meningitidis. Vaccine, in press. - PubMed
    1. Criss, A. K., K. A. Kline, and H. S. Seifert. 2005. The frequency and rate of pilin antigenic variation in Neisseria gonorrhoeae. Mol. Microbiol. 58:510-519. - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources