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Review
. 2010 Aug;12(8):882-9.
doi: 10.1093/neuonc/noq052. Epub 2010 May 14.

mTOR signaling in glioblastoma: lessons learned from bench to bedside

David Akhavan  1 , Timothy F Cloughesy, Paul S Mischel
Affiliations
Review

mTOR signaling in glioblastoma: lessons learned from bench to bedside

David Akhavan et al. Neuro Oncol. 2010 Aug.

Abstract

Phosphatidyl-inositol-3 kinases (PI3Ks) constitute a family of intracellular lipid kinases that are frequently hyperactivated in glioblastoma. The PI3K complex links growth factor signaling with cellular proliferation, differentiation, metabolism, and survival. Mammalian target of rapamycin (mTOR) acts both as a downstream effector and upstream regulator of PI3K, thus highlighting its importance in glioblastoma. This review highlights laboratory and clinical evidence of mTOR's role in glioblastoma. Mechanisms of escape from mTOR inhibition are also discussed, as well as future clinical strategies of mTOR inhibition.

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Figures

Fig. 1.
Fig. 1.
mTORC plays a key role in integrating signal transduction and metabolic pathways in glioblastoma. Schematic representation shows pathways that regulate or are regulated by mTOR signaling in glioblastoma, with the known frequency of molecular alterations in these genes.,,,
See this image and copyright information in PMC

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