Antitrypsin phenotypes in occupational organic diisocyanate asthma
Affiliations
- PMID: 2047579
Item in Clipboard
Antitrypsin phenotypes in occupational organic diisocyanate asthma
Res Commun Chem Pathol Pharmacol.
1991 Mar.
Abstract
Eleven subjects with clinical bronchial hyperreactivity towards hexamethylene diisocyanate used in their work and verified by spirometry before and after a shift were screened for their antitrypsin phenotypes by isoelectric focusing. One third were M1M1 homozygotes (over 50% in controls) while the rest were heterozygotes comprising one case, each, of M1S and M1I (expected frequencies 5 and 0.5%, respectively). It seems that heterozygous alpha 1-antitrypsin carriers may be at a greater risk to develop a pulmonary disease in the organic diisocyanate exposure than the homozygotes.
Similar articles
-
Phenotype-dependent inhibition of human alpha 1-antitrypsin by 1,6-hexane diamine in vitro.Biochem Int. 1988 Jul;17(1):141-5. Biochem Int. 1988. PMID: 3263859
-
Detoxification of an aliphatic amine by N-acetylation: experimental and clinical studies.Biochem Int. 1991 Jul;24(5):947-50. Biochem Int. 1991. PMID: 1663742
-
Inflammation and functional outcome in diisocyanate-induced asthma after cessation of exposure.Allergy. 2008 May;63(5):583-91. doi: 10.1111/j.1398-9995.2007.01606.x. Allergy. 2008. PMID: 18394133
-
New mechanistic model for organic diisocyanate-induced respiratory disease.Schweiz Med Wochenschr. 1999 Mar 27;129(12):465-7. Schweiz Med Wochenschr. 1999. PMID: 10231900 Review.
-
Genetic markers for occupational asthma.J Allergy Clin Immunol. 2002 May;109(5):774-6. doi: 10.1067/mai.2002.124664. J Allergy Clin Immunol. 2002. PMID: 11994698 Review. No abstract available.