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. 2007 May;3(3):351-64.
doi: 10.1586/1744666X.3.3.351.

Mechanisms of leukocyte trafficking in allergic diseases: insights into new therapies targeting chemokines and chemokine receptors

Masako Toda  1 , Takao Nakamura, Masaharu Ohbayashi, Yoshifumi Ikeda, Maria Dawson, Cho Cho Aye, Dai Miyazaki, Santa Jeremy Ono
Affiliations

Mechanisms of leukocyte trafficking in allergic diseases: insights into new therapies targeting chemokines and chemokine receptors

Masako Toda et al. Expert Rev Clin Immunol. 2007 May.

Abstract

Marked inflammatory infiltration by activated leukocytes is a characteristic feature of allergic diseases. Elucidation of the mechanisms of leukocyte trafficking in allergic diseases would identify targets to establish novel anti-inflammatory strategies for treatment of these diseases. Leukocyte trafficking is controlled by tissue-specific expression of chemokines and chemokine receptor expression on the leukocyte surface. Here, we review the role of chemokines and their receptors in leukocyte trafficking to inflammatory sites in allergic diseases and discuss therapeutic strategies targeting chemokine networks for treatment of these diseases.

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