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Comment
. 2010 May 18;17(5):421-3.
doi: 10.1016/j.ccr.2010.04.016.

Unveiling the secrets of the ancestral PI3 kinase Vps34

Paul Workman  1 , Rob L M van Montfort
Affiliations
Free article
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Unveiling the secrets of the ancestral PI3 kinase Vps34

Paul Workman et al. Cancer Cell. .
Free article

Abstract

Vps34 is the primordial member of the PI3 kinase family involved in vesicular trafficking, nutrient signaling, and autophagy. A report in Science unveils the Vps34 structure, providing new insights into the catalytic mechanism, explaining why Vsp34 is so difficult to inhibit, and facilitating design of chemical tools and potential drugs.

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