doi: 10.1016/j.ccr.2010.04.021.
Loss of 53BP1 is a gain for BRCA1 mutant cells
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- PMID: 20478525
- DOI: 10.1016/j.ccr.2010.04.021
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Loss of 53BP1 is a gain for BRCA1 mutant cells
Cancer Cell.
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Free article
Abstract
Mutations in BRCA1 predispose to tumorigenesis presumably from the inability to accurately repair DNA double-strand breaks by homologous recombination. Two new papers shed light on how loss of the DNA damage response protein 53BP1 reverses phenotypes of BRCA1 mutant cells, with potential clinical implications.
(c) 2010 Elsevier Inc. All rights reserved.
Comment in
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53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks.Cell. 2010 Apr 16;141(2):243-54. doi: 10.1016/j.cell.2010.03.012. Epub 2010 Apr 1. Cell. 2010. PMID: 20362325 Free PMC article.
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53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers.Nat Struct Mol Biol. 2010 Jun;17(6):688-95. doi: 10.1038/nsmb.1831. Epub 2010 May 9. Nat Struct Mol Biol. 2010. PMID: 20453858 Free PMC article.
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