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. 2010 May 18;17(5):481-96.
doi: 10.1016/j.ccr.2010.03.021.

TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer

Kira Bettermann  1 , Mihael Vucur, Johannes Haybaeck, Christiane Koppe, Jörn Janssen, Felix Heymann, Achim Weber, Ralf Weiskirchen, Christian Liedtke, Nikolaus Gassler, Michael Müller, Rita de Vos, Monika Julia Wolf, Yannick Boege, Gitta Maria Seleznik, Nicolas Zeller, Daniel Erny, Thomas Fuchs, Stefan Zoller, Stefano Cairo, Marie-Annick Buendia, Marco Prinz, Shizuo Akira, Frank Tacke, Mathias Heikenwalder, Christian Trautwein, Tom Luedde
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Free article

TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer

Kira Bettermann et al. Cancer Cell. .
Free article

Abstract

The MAP3-kinase TGF-beta-activated kinase 1 (TAK1) critically modulates innate and adaptive immune responses and connects cytokine stimulation with activation of inflammatory signaling pathways. Here, we report that conditional ablation of TAK1 in liver parenchymal cells (hepatocytes and cholangiocytes) causes hepatocyte dysplasia and early-onset hepatocarcinogenesis, coinciding with biliary ductopenia and cholestasis. TAK1-mediated cancer suppression is exerted through activating NF-kappaB in response to tumor necrosis factor (TNF) and through preventing Caspase-3-dependent hepatocyte and cholangiocyte apoptosis. Moreover, TAK1 suppresses a procarcinogenic and pronecrotic pathway, which depends on NF-kappaB-independent functions of the I kappaB-kinase (IKK)-subunit NF-kappaB essential modulator (NEMO). Therefore, TAK1 serves as a gatekeeper for a protumorigenic, NF-kappaB-independent function of NEMO in parenchymal liver cells.

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  • The MAP3K TAK1: a chock block to liver cancer formation.
    Malato Y, Willenbring H. Malato Y, et al. Hepatology. 2010 Oct;52(4):1506-9. doi: 10.1002/hep.23878. Hepatology. 2010. PMID: 20879030 No abstract available.
  • NEMO catches the FOX.
    Waidmann O, Piiper A, Zeuzem S. Waidmann O, et al. Gastroenterology. 2011 Mar;140(3):1102-3. doi: 10.1053/j.gastro.2011.01.007. Epub 2011 Jan 27. Gastroenterology. 2011. PMID: 21276766 No abstract available.

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