Review
doi: 10.1126/science.2047875.
Vaccinia virus: a tool for research and vaccine development
Affiliations
- PMID: 2047875
- DOI: 10.1126/science.2047875
Item in Clipboard
Review
Vaccinia virus: a tool for research and vaccine development
Science.
.
Abstract
Vaccinia virus is no longer needed for smallpox immunization, but now serves as a useful vector for expressing genes within the cytoplasm of eukaryotic cells. As a research tool, recombinant vaccinia viruses are used to synthesize biologically active proteins and analyze structure-function relations, determine the targets of humoral- and cell-mediated immunity, and investigate the immune responses needed for protection against specific infectious diseases. When more data on safety and efficacy are available, recombinant vaccinia and related poxviruses may be candidates for live vaccines and for cancer immunotherapy.
Similar articles
-
Genetically engineered poxviruses for recombinant gene expression, vaccination, and safety.Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11341-8. doi: 10.1073/pnas.93.21.11341. Proc Natl Acad Sci U S A. 1996. PMID: 8876137 Free PMC article. Review.
-
Replicating and host-restricted non-replicating vaccinia virus vectors for vaccine development.Dev Biol Stand. 1994;82:55-63. Dev Biol Stand. 1994. PMID: 7958483 Review.
-
Immunogenicity and safety of defective vaccinia virus lister: comparison with modified vaccinia virus Ankara.J Virol. 2002 Aug;76(15):7713-23. doi: 10.1128/jvi.76.15.7713-7723.2002. J Virol. 2002. PMID: 12097585 Free PMC article.
-
B5-deficient vaccinia virus as a vaccine vector for the expression of a foreign antigen in vaccinia immune animals.Virology. 2007 May 10;361(2):356-63. doi: 10.1016/j.virol.2006.11.020. Epub 2006 Dec 26. Virology. 2007. PMID: 17188733 Free PMC article.
-
Vaccinia virus: a suitable vehicle for recombinant vaccines?Arch Virol. 1989;106(1-2):127-39. doi: 10.1007/BF01311044. Arch Virol. 1989. PMID: 2669685 Review.
Cited by
-
Bcl-2 inhibits apoptosis and extends recombinant protein production in cells infected with Sindbis viral vectors.Cytotechnology. 1996 Jan;22(1-3):169-78. doi: 10.1007/BF00353936. Cytotechnology. 1996. PMID: 22358927
-
Expression of hepatitis E virus putative structural proteins in recombinant vaccinia viruses.Clin Diagn Lab Immunol. 1994 Mar;1(2):253-6. doi: 10.1128/cdli.1.2.253-256.1994. Clin Diagn Lab Immunol. 1994. PMID: 7496958 Free PMC article.
-
Chimeric influenza virus induces neutralizing antibodies and cytotoxic T cells against human immunodeficiency virus type 1.J Virol. 1993 Nov;67(11):6659-66. doi: 10.1128/JVI.67.11.6659-6666.1993. J Virol. 1993. PMID: 7692083 Free PMC article.
-
Use of licensed vaccines for active immunization of the immunocompromised host.Clin Microbiol Rev. 1998 Jan;11(1):1-26. doi: 10.1128/CMR.11.1.1. Clin Microbiol Rev. 1998. PMID: 9457426 Free PMC article. Review.
-
Immunogenicity and efficacy of DNA/MVA HIV vaccines in rhesus macaque models.Expert Rev Vaccines. 2017 Oct;16(10):973-985. doi: 10.1080/14760584.2017.1371594. Epub 2017 Sep 4. Expert Rev Vaccines. 2017. PMID: 28838267 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
