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Review
. 2010 May 18;121(19):2137-45.
doi: 10.1161/CIRCULATIONAHA.109.860171.

Cardiac titin: a multifunctional giant

Martin M LeWinter  1 , Henk Granzier
Affiliations
Review

Cardiac titin: a multifunctional giant

Martin M LeWinter et al. Circulation. .
No abstract available

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Figures

Figure 1
Figure 1
Schematic of titin in sarcomere.
Figure 2
Figure 2
Titin-based passive stiffness tuning-mechanisms. Differential splicing gives rise to isoforms of varying stiffness. During postnatal development (Devel) passive stiffness increases due to switching of fetal cardiac titin (FCT) to adult N2B and N2BA isoforms; hypothyroidism (HT) and dilated cardiomyopathy (DCM) alter splicing in the opposite direction. PKA and PKG phosphorylation reduce and PKC phosphorylation increases passive stiffness.
Figure 3
Figure 3
Proteins that bind to titin.
Figure 4
Figure 4
Schematic of N2B-based signalosome. Adaptor molecules belonging to the FHL family bind to N2B element and sequester kinases of the MAPK signaling pathway. Bottom: increased N2B strain (PEVK KO) results in additional signalosomes, shifting the balance towards hypertrophy; absence of the N2B element (N2B KO) results in hypertrophy.
See this image and copyright information in PMC

References

    1. Furst DO, Osborn M, Nave R, Weber K. The organization of titin filaments in the half-sarcomere revealed by monoclonal antibodies in immunoelectron microscopy: a map of ten nonrepetitive epitopes starting at the Z line extends close to the M line. J Cell Biol. 1988;106:1563–72. - PMC - PubMed
    1. Labeit S, Kolmerer B. Titins: giant proteins in charge of muscle ultrastructure and elasticity. Science. 1995;270:293–6. - PubMed
    1. Helmes M, Trombitas K, Centner T, Kellermayer M, Labeit S, Linke WA, Granzier H. Mechanically driven contour-length adjustment in rat cardiac titin's unique N2B sequence: titin is an adjustable spring. Circ Res. 1999;84:1339–52. - PubMed
    1. Wang K. Titin/connectin and nebulin: giant protein rulers of muscle structure and function. Adv Biophys. 1996;33:123–34. - PubMed
    1. Trinick J. Titin and nebulin: protein rulers in muscle? Trends Biochem Sci. 1994;19:405–9. - PubMed

Publication types