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. 1983 Jun;80(1 Suppl):44s-9s.
doi: 10.1038/jid.1983.12.

Epidermal lipids, barrier function, and desquamation

P M Elias  1
Affiliations

Epidermal lipids, barrier function, and desquamation

P M Elias. J Invest Dermatol. 1983 Jun.

Abstract

Based on recent morphologic, histochemical, and biochemical data, we propose a heterogeneous two-compartment model of the stratum corneum that ascribes a special role for intercellular lipids in the regulation of stratum corneum barrier function and desquamation. The evidence in favor of the model and several predictions based on the model are surveyed in this review.

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