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. 2010 Mar 29;8(4):941-9.
doi: 10.3390/md8040941.

Five sesquiterpenoids from a marine-derived fungus Aspergillus sp. isolated from a gorgonian Dichotella gemmacea

Mei-Yan Wei  1 , Chang-Yun Wang, Qing-Ai Liu, Chang-Lun Shao, Zhi-Gang She, Yong-Cheng Lin
Affiliations

Five sesquiterpenoids from a marine-derived fungus Aspergillus sp. isolated from a gorgonian Dichotella gemmacea

Mei-Yan Wei et al. Mar Drugs. .

Abstract

Three new phenolic bisabolane-type sesquiterpenoids: (+)-methyl sydowate (1), 7-deoxy-7,14-didehydrosydonic acid (2), and 7-deoxy-7,8-didehydrosydonic acid (3), together with two known fungal metabolites were isolated from the fermentation broth of a marine-derived fungus Aspergillus sp., which was isolated in turn from a gorgonian Dichotella gemmacea collected from the South China Sea. Their structures were elucidated by combined spectroscopic methods, and the structure of 1 was further confirmed by single-crystal X-ray data.

Keywords: Aspergillus sp.; gorgonian Dichotella gemmacea; phenolic bisabolane-type sesquiterpenoid.

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Figures

Figure 1
Figure 1
Structures of compounds 1–5.
Figure 2
Figure 2
ORTEP drawing for methyl sydowate (1).
See this image and copyright information in PMC

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