Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2012 Dec;32(12):4023-6.
doi: 10.1007/s00296-010-1525-z. Epub 2010 May 18.

A fatal case of acute exacerbation of interstitial lung disease in a patient with rheumatoid arthritis during treatment with tocilizumab

Shin-Ya Kawashiri  1 , Atsushi Kawakami, Noriho Sakamoto, Yuji Ishimatsu, Katsumi Eguchi
Affiliations
Case Reports

A fatal case of acute exacerbation of interstitial lung disease in a patient with rheumatoid arthritis during treatment with tocilizumab

Shin-Ya Kawashiri et al. Rheumatol Int. 2012 Dec.

Abstract

A 68-year-old man, who was a patient with established rheumatoid arthritis (RA) with RA-associated interstitial lung disease (RA-ILD) and pulmonary emphysema, began taking tocilizumab. Subsequently, he developed dyspnea parallel to improvement of RA. At 10 months after the administration of tocilizumab, he was urgently admitted because of exacerbation of ILD. He died despite receiving steroid pulse therapy and antibiotic therapy on a respirator. This is the first case report to describe the exacerbation of ILD during treatment with tocilizumab in the postmarketing surveillance (PMS) period.

PubMed Disclaimer

References

    1. Int Immunopharmacol. 2005 Nov;5(12):1731-40 - PubMed
    1. Lancet. 2008 Mar 22;371(9617):987-97 - PubMed
    1. Ann Rheum Dis. 2008 Feb;67(2):189-94 - PubMed
    1. Scand J Rheumatol. 2004;33(4):276-7 - PubMed
    1. Arthritis Rheum. 2009 Mar 15;61(3):305-12 - PubMed

Publication types

MeSH terms

LinkOut - more resources