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Review
. 2011 Feb;38(2):873-8.
doi: 10.1007/s11033-010-0179-y. Epub 2010 May 18.

The emerging role of adipokines in osteoarthritis: a narrative review

Peng-fei Hu  1 , Jia-peng Bao, Li-dong Wu
Affiliations
Review

The emerging role of adipokines in osteoarthritis: a narrative review

Peng-fei Hu et al. Mol Biol Rep. 2011 Feb.

Abstract

Osteoarthritis (OA) is a most common multifactorial degenerative joint disease in elderly individuals. OA is affecting severely the quality of life of patients, while the causes of OA are not completely understood. Age, obesity, the female sex, and previous injury are considered as significant risk factors. Recently, increased levels of adipokines which are mainly produced by adipocytes have been detected in patients with osteoarthritis. Moreover, studies on different adipokines all reveal that they have played proinflammatory and catabolic/anabolic roles during the pathophysiology of OA. In the present review, we summarize current data on the effect of the adipose tissue-derived hormones leptin, adiponectin, resistin and visfatin on initiation and progression of OA.

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