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. 2010 Jun 18;75(12):4304-6.
doi: 10.1021/jo1004058.

Synthesis of an acyltrifluoroborate and its fusion with azides to form amides

Gary A Molander  1 , Jessica Raushel, Noel M Ellis
Affiliations

Synthesis of an acyltrifluoroborate and its fusion with azides to form amides

Gary A Molander et al. J Org Chem. .

Abstract

A uniquely stable acyl potassium trifluoroborate, potassium (2-phenylacetyl)trifluoroborate, has been synthesized and isolated. In the presence of an activating Lewis acid, this reagent reacts with azides to form amides in good yields.

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Figures

Figure 1
Figure 1
Related acyl boron and acyl boron equivalents.
Scheme 1
Scheme 1. Preparation of Acyltrifluoroborate 7
Scheme 2
Scheme 2. Plausible Reaction Mechanism
See this image and copyright information in PMC

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