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Case Reports
. 2010:154:A1634.

[Fatal pneumonitis due to oseltamivir-resistant new influenza A(H1N1) in the case of an intensive care patient]

[Article in Dutch]
Heleen Aardema  1 , Jaap E Tulleken, Ries J M van den Biggelaar, Bert A Wolters, Corine M de Jager, Charles A B Boucher, Annelies Riezebos-Brilman
Affiliations
  • PMID: 20482913
Case Reports

[Fatal pneumonitis due to oseltamivir-resistant new influenza A(H1N1) in the case of an intensive care patient]

[Article in Dutch]
Heleen Aardema et al. Ned Tijdschr Geneeskd. 2010.

Abstract

A 58-year-old man was submitted to our intensive care ward with respiratory failure due to pneumonitis. He had previously been treated for non-Hodgkin lymphoma by autologous stem cell transplantation, as a result of which bone marrow function was reduced. Further analysis showed infection with new influenza A(H1N1); typing revealed an oseltamivir-resistant subpopulation (H275Y). The patient was treated with oseltamivir and intravenously with zanamivir, but died of respiratory disease progression. This is the first published case of oseltamivir-resistant new influenza A(H1N1) infection in the Netherlands.

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