[Models in toxicology]

Abstract

The paper outlines a methodological approach to measurement of sale levels of acute and chronic chemical exposure in the toxicological experiment by using the well-known and proposed techniques of mathematical simulation of time-effect, dose-effect, and time-dose relationships and after-transition to the models of dose-status relationships while making an integral diagnostic evaluation of the body status. It is shown that it is possible to construct the diagnostic scales that differentiate the conditions of physiological normal status, good and bad adaptation, mild, moderate, and severe intoxication. By using organophosphorus pesticides, such as ciodrin and aphos, and lead nitrate as an example, the author considers if the models can be used in the sanitary standardization of xenobiotics.