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Review
. 2010 Aug;13(4):472-7.
doi: 10.1016/j.pbi.2010.04.007. Epub 2010 May 17.

NB-LRR proteins: pairs, pieces, perception, partners, and pathways

Timothy K Eitas  1 , Jeffery L Dangl
Affiliations
Review

NB-LRR proteins: pairs, pieces, perception, partners, and pathways

Timothy K Eitas et al. Curr Opin Plant Biol. 2010 Aug.

Abstract

In plants, many of the innate immune receptors or disease resistance (R) proteins contain a NB-LRR (Nucleotide-binding site, Leucine-rich repeat) structure. The recent findings regarding NB-LRR signaling are summarized in this article. An emerging theme is that two NB-LRRs can function together to mediate disease resistance against pathogen isolates. Also, recent results delineate the NB-LRR protein fragments that are sufficient to initiate defense signaling. Importantly, distinct fragments of different NB-LRRs are sufficient for function. Finally, we describe the new roles of accessory proteins and downstream host genes in NB-LRR signaling.

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Figures

Figure 1
Figure 1. Domain structure and pathogen isolates of NB-LRR pairs
Top row: NB-LRR pairs in Arabidopsis and Tobacco. Black lettering represents pathogen isolate. Blue lettering represents avr gene product. Bottom row: NB-LRR pairs in Wheat and Rice. Black lettering represents pathogen isolate.
See this image and copyright information in PMC

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