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. 2010 Jul;140(7):1205-10.
doi: 10.3945/jn.110.122804. Epub 2010 May 19.

Honoring Clive McCay and 75 years of calorie restriction research

Roger B McDonald  1 , Jon J Ramsey
Affiliations

Honoring Clive McCay and 75 years of calorie restriction research

Roger B McDonald et al. J Nutr. 2010 Jul.
No abstract available

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Figures

FIGURE 1
FIGURE 1
Survival curves generated from the data of McCay et al. (1) for male (A) and female (A) rats consuming ad libitum or CR.
FIGURE 2
FIGURE 2
Maximal lifespan of male mice that consumed ad libitum and varying levels of CR. Values above bars are approximate percentages of CR. Adapted with permission from (53). 1 kcal = 4.186 kJ.
FIGURE 3
FIGURE 3
Number of original research reports using CR published between 1986 and 2009. Census was collected from a PubMed search using the key words “calorie restriction or dietary restriction and aging.” Reviews, commentaries, and studies emphasizing obesity in humans were excluded from the count. Note that the number of publications in the 4-y period of 2006–2009 is just slightly less than the total number of papers published in the 15-y period between 1986 and 2000.
See this image and copyright information in PMC

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References

    1. McCay CM, Crowell MF, Maynard LA. The effect of retarded growth upon the length of life span and upon the ultimate body size. J Nutr. 1935;10:63–79. - PubMed
    1. Yu BP, Masoro EJ, Murata I, Bertrand HA, Lynd FT. Life span study of SPF Fischer 344 male rats fed ad libitum or restricted diets: longevity, growth, lean body mass and disease. J Gerontol. 1982;37:130–41. - PubMed
    1. Cheney KE, Liu RK, Smith GS, Leung RE, Mickey MR, Walford RL. Survival and disease patterns in C57BL/6J mice subjected to undernutrition. Exp Gerontol. 1980;15:237–58. - PubMed
    1. Guarente L. Calorie restriction and SIR2 genes–towards a mechanism. Mech Ageing Dev. 2005;126:923–8. - PubMed
    1. Houthoofd K, Vanfeteren JR. Longevity effect of dietary restriction in Caenorhabditis elegans. Exp Gerontol. 2006;41:1026–32. - PubMed

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