Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Feb;13(2):161-4.
doi: 10.1007/BF02533260.

Inhibition of diacylglycerol:CDPcholine cholinephosphotransferase activity by dimethylaminoethyl p-chlorophenoxyacetate

S Parthasarathy, R K Cady, D S Kraushaar, N E Sladek, W J Baumann

Inhibition of diacylglycerol:CDPcholine cholinephosphotransferase activity by dimethylaminoethyl p-chlorophenoxyacetate

S Parthasarathy et al. Lipids. 1978 Feb.

Abstract

Cholinephosphotransferase [EC 2.7.8.2] activity of rat liver microsomes, with 1,2-di-0-[3H]acyl glycerol or 1-0-hexadecanoyl [U-14C]ethanediol as substrate, was inhibited by N,N-dimethylaminoethyl p-chlorophenoxyacetate (centrophenoxine). Inhibition progressed in a linear fashion with increasing drug levels and was complete at 30 mM concentration. It appears that the microsomal enzyme was largely affected by the drug itself because the hydrolysis products of centrophenoxine, viz., N,N-dimethylaminoethanol and p-chlorophenoxyacetic acid, were less inhibitory.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Biochim Biophys Acta. 1972 Apr 18;260(4):571-82 - PubMed
    1. Biochem Biophys Res Commun. 1974 Jul 10;59(1):100-7 - PubMed
    1. J Biol Chem. 1963 Aug;238:2615-9 - PubMed
    1. J Pharmacol Exp Ther. 1977 Jan;200(1):17-24 - PubMed
    1. J Pharmacol Exp Ther. 1977 May;201(2):518-26 - PubMed

Publication types

MeSH terms

LinkOut - more resources