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Editorial
. 2010 Jun;30(6):1075-7.
doi: 10.1161/ATVBAHA.110.206573.

Atherosclerosis and abdominal aortic aneurysm: cause, response, or common risk factors?

Jonathan Golledge, Paul E Norman
Editorial

Atherosclerosis and abdominal aortic aneurysm: cause, response, or common risk factors?

Jonathan Golledge et al. Arterioscler Thromb Vasc Biol. 2010 Jun.
No abstract available

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Figures

Figure
Figure
According to Theory 1 (filled arrows) environmental and genetic risk factors lead to development of aortic atherosclerosis. Resultant positive remodeling, intimal thrombosis and release of pro-inflammatory cytokines stimulate secondary matrix degradation and adventitial inflammation which promotes AAA development. According to Theory 2 (stripped arrows) environmental and genetic risk factors directly stimulate aortic medial degradation and adventitial inflammation leading to AAA formation which secondarily stimulates intimal atherosclerosis. More likely both pathways act to some extent with the relative proportion varying from patient to patient depending on the risk profile. ECM= Extracellular matrix.
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References

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