Comment
doi: 10.1126/scitranslmed.3001082.
Insights into therapy: tryptophan oxidation and HIV infection
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- PMID: 20484729
- DOI: 10.1126/scitranslmed.3001082
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Comment
Insights into therapy: tryptophan oxidation and HIV infection
Sci Transl Med.
.
Abstract
New data from Favre and colleagues strengthen the link between activation of the tryptophan oxidation (TOx) pathway--via the indoleamine 2,3-dioxygenase enzymes IDO1 and IDO2--and chronic inflammation in progressive HIV disease. It can now be appreciated that a pathogenic TOx activation cycle exists in HIV. TOx regulation is a therapeutic target for other diseases, such as cancer and autoimmune disorders. Here TOx control is examined with an eye to eventual therapeutic intervention in HIV disease.
Comment on
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