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Comment
. 2010 May 19;2(32):32ps23.
doi: 10.1126/scitranslmed.3001082.

Insights into therapy: tryptophan oxidation and HIV infection

Michael F Murray  1
Affiliations
Comment

Insights into therapy: tryptophan oxidation and HIV infection

Michael F Murray. Sci Transl Med. .

Abstract

New data from Favre and colleagues strengthen the link between activation of the tryptophan oxidation (TOx) pathway--via the indoleamine 2,3-dioxygenase enzymes IDO1 and IDO2--and chronic inflammation in progressive HIV disease. It can now be appreciated that a pathogenic TOx activation cycle exists in HIV. TOx regulation is a therapeutic target for other diseases, such as cancer and autoimmune disorders. Here TOx control is examined with an eye to eventual therapeutic intervention in HIV disease.

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