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Review
. 2010 Jul;22(4):368-74.
doi: 10.1097/BOR.0b013e3283393807.

Interactions between gut inflammation and arthritis/spondylitis

Peggy Jacques  1 , Dirk Elewaut, Herman Mielants
Affiliations
Review

Interactions between gut inflammation and arthritis/spondylitis

Peggy Jacques et al. Curr Opin Rheumatol. 2010 Jul.

Abstract

Purpose of review: The spectrum of spondyloarthritis is characterized by the intriguing co-occurrence of gut and joint inflammation, although no obvious anatomical link exists.

Recent findings: Data from animal models identify stromal cells as important players in pathogenesis, although signalling through TNFRI appeared to be sufficient for development of combined gut and joint inflammation. Interleukin-23 receptor was identified as a susceptibility locus for ankylosing spondylitis.

Summary: Human genome studies combined with animal model research provide us with new evidence in the fascinating field of the gut-joint axis. However, how these newly identified genetic associations can influence the immunological environment remains to be elucidated.

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