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. 2010 Jul 15;55(1):165-70.
doi: 10.1002/pbc.22513.

Characteristics of responders to a request for a buccal cell specimen among survivors of childhood cancer and their siblings

Kirsten K Ness  1 , Chenghong Li, Pauline A Mitby, Gretchen A Radloff, Ann C Mertens, Stella M Davies, Sue Hammond, Gregory T Armstrong, Leslie L Robison
Affiliations

Characteristics of responders to a request for a buccal cell specimen among survivors of childhood cancer and their siblings

Kirsten K Ness et al. Pediatr Blood Cancer. .

Abstract

Purpose: Analysis of biological samples in large cohort studies may provide insight into the mechanism of, and risk factors for, disease onset and progression.

Methods: This study describes the methods used to collect biological samples from a large multi-center cohort of childhood cancer survivors and siblings of childhood cancer survivors and evaluates the predictors of a positive response among these individuals.

Results: Among survivors, female sex, white race/ethnicity, college graduation, never smoking, accessing the healthcare system in the past 2 years, and having a second malignant neoplasm were the strongest predictors of returning a sample. Among siblings, a similar demographic profile defined those likely to submit the requested sample.

Conclusion: To reduce selection bias and increase the value of these samples for future analysis, additional phone calls and reminders targeting non-responders are needed to improve response rates among those least likely to respond to a single mailed request.

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Figures

Figure 1
Figure 1
Frequently Asked Questions Regarding Oragene® Saliva Collection and Usual Research Staff Responses
Figure 1
Figure 1
Frequently Asked Questions Regarding Oragene® Saliva Collection and Usual Research Staff Responses
See this image and copyright information in PMC

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