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. 2010 May 20:10:218.
doi: 10.1186/1471-2407-10-218.

Aberrant expression of CD133 protein correlates with Ki-67 expression and is a prognostic marker in gastric adenocarcinoma

Po Zhao  1 , Yazhuo Li, Yali Lu
Affiliations

Aberrant expression of CD133 protein correlates with Ki-67 expression and is a prognostic marker in gastric adenocarcinoma

Po Zhao et al. BMC Cancer. .

Abstract

Background: The relationships between the expression of CD133, Ki-67 and prognosis in gastric adenocarcinoma are unknown and needs exploring.

Methods: The samples of gastric adenocarcinoma from 336 Chinese patients with follow-up were analyzed for CD133 and Ki-67 protein expressions by immunohistochemical method.

Results: CD133 was expressed in up to 57.4% (193/336) of this group of gastric carcinoma. The expression of CD133 was significantly higher in carcinoma than in normal (P = 0.0001) and dysplastic mucosas (P = 0.004). CD133 was positive corresponded with the tumour size, grade, infiltrative depth and clinical stage (all P < 0.05). The overall mean survival time of the patients with CD133 positive expression was shorter than that of patients with negative expression (P = 0.0001). The expression of CD133 has a positive correlation with that of Ki-67 (r = 0.188, P = 0.001) in gastric adenocarcinoma. CD133 was an independent prognostic indicator. (P = 0.0001).

Conclusions: It is suggested that CD133 may play an important role in the evolution of gastric adenocarcinoma and should be considered as a potential marker for the prognosis.

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Figures

Figure 1
Figure 1
Expression of CD133 protein in gastric adenocarcinoma. CD133 expressed positive in the membrane and cytoplasm of cancer cells in poorly-differentiated adenocarcinoma (grade 3). (CD133 ×400).
Figure 2
Figure 2
Expression of CD133 protein in gastric adenocarcinoma. CD133 predominantly localized in the membrane and cytoplasm around the lumen of cancerous glands in well-differentiated adenoocarcinoma (grade 1). (CD133 ×400).
Figure 3
Figure 3
CD133 overexpressed in the membrane and cytoplasm of cancer cells located in invasive depth (CD133 ×400).
Figure 4
Figure 4
Kaplan-Meier survival analysis by CD133 status (n = 336). The y-axis represents the percentage of patients; the x-axis, their survival in months. The green line represents CD133-positive patients with a trend of worse survival than the blue line representing CD133-negative gastric carcinoma patients (Log rank = 53.80; P = 0.0001). Mean survival times were 36.3 months for the CD133- positive group and 66.0 months for the CD133-negative group.
Figure 5
Figure 5
Ki-67 expressed in the nucleus of cancer cells located in invasive depth (Ki-67 ×400).
See this image and copyright information in PMC

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