doi: 10.1016/0197-0186(81)90027-9.
Polyamine metabolism and function in brain
Affiliations
- PMID: 20487812
- DOI: 10.1016/0197-0186(81)90027-9
Item in Clipboard
Polyamine metabolism and function in brain
Neurochem Int.
1981.
Abstract
Putrescine, spermidine and spermine are simple alipathic polycations of ubiquitous occurrence. The pathways of biosynthesis and catabolism, and changes of the concentrations of these compounds in brain under various conditions are discussed. The pharmacological properties of the polyamines have not yet revealed functions which are characteristic only for the CNS, but preliminary evidence suggests structural roles in membranes and a modulatory function in certain neuronal systems.
Similar articles
-
Catabolism of polyamines.Amino Acids. 2004 Jun;26(3):217-33. doi: 10.1007/s00726-004-0070-z. Epub 2004 Apr 20. Amino Acids. 2004. PMID: 15221502 Review.
-
Concurrent overexpression of ornithine decarboxylase and spermidine/spermine N(1)-acetyltransferase further accelerates the catabolism of hepatic polyamines in transgenic mice.Biochem J. 2001 Sep 1;358(Pt 2):343-8. doi: 10.1042/0264-6021:3580343. Biochem J. 2001. PMID: 11513732 Free PMC article.
-
Relative abilities of bis(ethyl) derivatives of putrescine, spermidine, and spermine to regulate polyamine biosynthesis and inhibit L1210 leukemia cell growth.Cancer Res. 1987 Jun 1;47(11):2821-5. Cancer Res. 1987. PMID: 3567905
-
Modulation of learning and memory by natural polyamines.Pharmacol Res. 2016 Oct;112:99-118. doi: 10.1016/j.phrs.2016.03.023. Epub 2016 Mar 22. Pharmacol Res. 2016. PMID: 27015893 Review.
-
Physiology of the natural polyamines putrescine, spermidine and spermine.Med Biol. 1975 Jun;53(3):121-47. Med Biol. 1975. PMID: 169440 Review.
Cited by
-
Polyamines in Ovarian Aging and Disease.Int J Mol Sci. 2023 Oct 18;24(20):15330. doi: 10.3390/ijms242015330. Int J Mol Sci. 2023. PMID: 37895010 Free PMC article. Review.
-
(R,R)-1,12-Dimethylspermine can mitigate abnormal spermidine accumulation in Snyder-Robinson syndrome.J Biol Chem. 2020 Mar 6;295(10):3247-3256. doi: 10.1074/jbc.RA119.011572. Epub 2020 Jan 29. J Biol Chem. 2020. PMID: 31996374 Free PMC article.
-
Suicide and the polyamine system.CNS Neurol Disord Drug Targets. 2013 Nov;12(7):980-8. doi: 10.2174/18715273113129990095. CNS Neurol Disord Drug Targets. 2013. PMID: 24040803 Free PMC article. Review.
-
Decreased hyperammonaemia and orotic aciduria due to inactivation of ornithine aminotransferase in mice with a hereditary abnormal ornithine carbamoyltransferase.J Inherit Metab Dis. 1994;17(6):691-703. doi: 10.1007/BF00712011. J Inherit Metab Dis. 1994. PMID: 7707692
-
Implication of the polyamine system in mental disorders.J Psychiatry Neurosci. 2008 Mar;33(2):102-10. J Psychiatry Neurosci. 2008. PMID: 18330456 Free PMC article. Review.
LinkOut - more resources
Full Text Sources
