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Review
. 2010 Jun;31(2):309-18.
doi: 10.1016/j.ccm.2010.02.004.

Neurobiology of sleep

Brandon S Lu  1 , Phyllis C Zee
Affiliations
Free article
Review

Neurobiology of sleep

Brandon S Lu et al. Clin Chest Med. 2010 Jun.
Free article

Abstract

The neurobiology of sleep is introduced in the context of interacting wake and sleep systems. Specifically, the transitions from wake to sleep and from non-rapid eye movement to rapid eye movement sleep are discussed based on the flip-flop switch hypothesis. Regulation of wake and sleep according to the opposing homeostatic and circadian systems are also presented.

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