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. 2010 Jul 30;178(2):433-6.
doi: 10.1016/j.psychres.2010.04.048. Epub 2010 May 20.

COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome

Vandana Shashi  1 , Timothy D Howard, Matcheri S Keshavan, Jessica Kaczorowski, Margaret N Berry, Kelly Schoch, Edward J Spence, Thomas R Kwapil
Affiliations

COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome

Vandana Shashi et al. Psychiatry Res. .

Abstract

The COMT gene is thought to contribute to the cognitive/psychiatric phenotypes in 22q11.2 deletion syndrome. We measured these manifestations against the Val/Met alleles of the COMT gene, in 40 nonpsychotic 22q11DS children. The Val allele was associated with poor IQ, processing speed, executive function and a higher frequency of anxiety disorders, underscoring the importance of the COMT gene in the childhood psychopathology in 22q11DS.

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