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. 2010 Jun 15;20(12):3515-7.
doi: 10.1016/j.bmcl.2010.04.136. Epub 2010 May 18.

Synthesis of the Cyanine 7 labeled neutrophil-specific agents for noninvasive near infrared fluorescence imaging

Li Xiao  1 , Yi Zhang, Zhongqiu Liu, Min Yang, Lin Pu, Dongfeng Pan
Affiliations

Synthesis of the Cyanine 7 labeled neutrophil-specific agents for noninvasive near infrared fluorescence imaging

Li Xiao et al. Bioorg Med Chem Lett. .

Abstract

A neutrophil-binding peptide, cinnamoyl-F(D)LF(D)LF (cFLFLF), was labeled with the near infrared (NIR) fluorophore, Cyanine 7 (Cy7). This construct was modified with a polyethylene glycol (PEG, M(W) 3.4 kDa) moiety in order to increase its solubility and bioavailability to circulating neutrophils. A preliminary noninvasive fluorescence imaging of a mouse model of ear inflammation with the fluorescent probe is presented.

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