Review
T-cell reactivity to purified lipophosphoglycan from Leishmania major: a model for analysis of the cellular immune response to microbial carbohydrates
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- PMID: 2049034
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Review
T-cell reactivity to purified lipophosphoglycan from Leishmania major: a model for analysis of the cellular immune response to microbial carbohydrates
Behring Inst Mitt.
1991 Feb.
Abstract
The major macromolecule on the surface of Leishmania major promastigotes is a lipophosphoglycan (LPG). This glycoconjugate plays a key role in determining infectivity and survival of parasites in the mammalian host cell. In addition, L. major LPG is able to induce a host-protective immune response. In this article, we summarise the evidence for recognition of highly purified LPG by T cells and we discuss the potential mechanisms of T-cell stimulation by this non-protein antigen.
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