Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Feb 22;373(2):209-10.
doi: 10.1007/BF00584863.

The sensitivity of pineal gland beta-receptors appears to be dependent upon calcium ions

M Wilkinson

The sensitivity of pineal gland beta-receptors appears to be dependent upon calcium ions

M Wilkinson. Pflugers Arch. .

Abstract

Rat pineals were used in vitro to demonstrate that calcium antagonists induce a hyposensitive response to stimulation of serotonin N-acetyl transferase (NAT) by the beta-agonist isoproterenol or by dibutyryl cyclic AMP. Mn2+, Co2+ and La3+ at 10(-3)M all significantly reduce the effects of isoproterenol stimulation. In addition, the two enantiomers of D600 also inhibit NAT induction, the D-form slightly more effectively than the L-form. Interestingly, La3+ is also able to inhibit NAT after DBcAMP, indicating that Ca2+ can also control enzyme induction at an intracellular site beyond the beta-receptor.

PubMed Disclaimer

References

    1. Mol Pharmacol. 1977 Jul;13(4):735-45 - PubMed
    1. J Pharmacol Exp Ther. 1973 Sep;186(3):516-27 - PubMed
    1. Neurosci Lett. 1976 Mar;2(1):29-33 - PubMed
    1. Adv Cyclic Nucleotide Res. 1975;5:163-78 - PubMed
    1. J Physiol. 1973 Jun;231(2):96P-98P - PubMed

LinkOut - more resources